Interesting. Gonna give this to Peter. His suit is extremely versatile and abilities and I doubt invisibility will get the better of him when his Spider-Senses could easily catch Mysterio trying to shoot him while cloaked. Also, Spidey's martial arts as shown in FFH would likely overwhelm Predator. If the worst comes to the worst, Spidey can always just summon EDITH drones while attacking Predator.