Main antagonists that a self-contained story circles around, or recurrent archenemies of a main protagonist.
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A
- A Serpente
- A.L.I.E.
- Abaddon the Despoiler
- Abby Anderson
- Abe no Seimei (Oniwakamaru The Visitor)
- Abeloth
- Abigail (Devil May Cry)
- Abo and Kado
- Abomination (Marvel Cinematic Universe)
- Abomination (Ultimate Destruction)
- Absorbing Man (2003 Movie Version)
- Abyss (Izuna)
- Abyss (Marvel vs. Capcom)
- Abzu
- Abzu (MonsterVerse)
- Acacia (Green Worldz)
- Acacia (Toriko)
- Ace (Rubyquest)
- Acheron Hive
- Achi
- Achilles Davenport
- Acnologia
- Adam (Nier: Automata)
- Adam Arclight
- Addie Fitch
- Adheera
- Adolf Hitler (Kung Fury)
- Agatha Prenderghast
- Agatha Trunchbull
- Agatio (Golden Sun)
- Agent Smith
- Agents (The Matrix)
- Agon
- Ahmanet (Dark Universe)
- Ai Enma
- Ai Magase
- Aicus
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Aizono Mio
- Ajax (FOX)
- Ajax the Gorilla (Disney)
- Akan
- Akim Papradon
- Akira Nishikiyama
- Akron
- Aku
- Akuma (Asura's Wrath)
- Akuma (Marvel vs. Capcom)
- Akuma (Street Fighter)
- Akuma (Udon Comics)
- Akuma Shogun (Goldman)
- Al Mualim (Assassin's Creed)
- Alameda Slim
- Albert Wesker
- Albert Wesker (Marvel vs. Capcom)
- Aldrich Killian (Marvel Cinematic Universe)
- Alduin
- Aleister Crowley (Toaru Majutsu no Index)
- Alex (Golden Sun)
- Alex Mahone
- Alexia Ashford
- Alexios
- Alexis Kerib (SSSS.Gridman)
- Alfis (Piggy)
- Algol (Dino Crisis)
- Algol (Soul Calibur)
- Alien (Alien: The Original Screenplay)
- Alien Intruder
- Alien Pods (Godzilla)
- Alien Robots (1982 Hulk Cartoon)
- Alien Train Tank
- Aliens (Galaga)
- All For One
- All-Terraintula
- Allegro (Vampire in the Garden)
- Allosaurus (Carnivores)
- Alovenus
- Aloysius Kallig
- Alpha Gang Trio
- Altair (Re:Creators)
- Alucard (Rosario + Vampire)
- AM (I Have No Mouth, and I Must Scream)
- Amadeus Syndicate
- Amahl Farouk (FX)
- Amanda Young
- Ambassador Darkness
- Amber Freeman
- Amhuluk (MonsterVerse)
- Ammit (Marvel Cinematic Universe)
- Amon (Legend of Korra)
- Amon (StarCraft)
- Amorges (Assassin's Creed)
- Amou Kirukiru
- Amphibion
- Amy Martin
- Anankos
- Anck-Su-Namun (The Mummy)
- Andrew Detmer
- Andrew Scott
- Andrewsarchus (Carnivores)
- Android 13
- Andross
- André (Rayman)
- André Linoge
- Angel of Light and Shadow
- Angra Mainyu (Fate)
- Angus Bumby (Alice : Madness Returns)
- Animus (Lucifer and The Biscuit Hammer)
- Ankylosaurus (Carnivores)
- Ankylosaurus (Warpath: Jurassic Park)
- Anon (Law of Ueki)
- Another Decade (Swartz)
- Another Kuuga (Tid)
- Ansem, Seeker of Darkness
- Anti
- Anti-Man (Marvel Comics)
- Anti-Monitor
- Anti-Monitor (CW)
- Anti-Spiral
- Anton Chigurh
- Aoandon
- Apemen (Nosferatu)
- Apocalymon
- Apocalypse (FOX)
- Apocalypse (Marvel Comics)
- Apocalypse (Marvel vs. Capcom)
- Apollo (Saint Seiya)
- Apollo Creed
- Apollo Geist (DCD)
- Apollyon (For Honor)
- Apolyon (Chaos Comics)
- Apophis (Riordan)
- Aqua Slug
- Aquila
- Arawin
- Arba
- Arcadius/Cade
- Arcann
- Arch-Illager
- Archer (Pokémon)
- Archie (Pokémon)
- Archnemon
- Ardyn Izunia
- Ares (DC Comics)
- Ares (DC Extended Universe)
- Arfoire (Deity of Sin)
- Arfoire (Sisters VS Sisters)
- Argosax
- ARIA
- Arius
- Arkham
- Arlong (Netflix)
- Armando Salazar
- Armillaria
- Arpin Lusène
- Art the Clown
- Artemis (Saint Seiya)
- Arthur Pendragon (Nanatsu no Taizai)
- Artorius Collbrande
- Arvis (Fire Emblem)
- Asav
- Asdrubael Vect
- Ashera
- Ashhart
- Ashnard
- Askeladd
- Asriel Dreemurr (Flowey)
- Assassin Asha
- Astaroth (Ghosts 'n Goblins)
- Astrea (For Honor)
- Atriox
- Atropos (CW)
- Atropos (God of War)
- Audamorze
- Audrey II (1986)
- Augustus (The Troop)
- Australis
-
Avatar of Calamity
- Avatar of Evil
- Aventurine
- Axor
- Ayaka Kamimochi
- Azazel (Tekken)
- Azog the Defiler (The Hobbit Films)
- Azrail
- Azwel